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Simparica

Simparica

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Simparica

Monthly Flea, Tick & Mite Protection

Simparica is a highly effective oral flea and tick preventative medication designed specifically for dogs. Made with the active ingredient sarolaner, Simparica targets the nervous system of these pests, rendering them paralyzed before causing their death. A single dose offers a rapid onset of action, killing fleas before they can lay eggs and reducing the risk of tick-borne diseases. Given monthly, Simparica not only eliminates existing infestations but also offers consistent, long-lasting protection against future ones. Its extended effectiveness ensures that pets remain safeguarded throughout the entire month.


Disclaimer: This Simparica Size Chart is intended for general information purposes only and does not serve as professional veterinary counsel. It's imperative to consult with a qualified veterinarian for definitive guidance and to discuss any particular issues or inquiries related to your pet's well-being and care.

Frequently Asked Questions

What is Simparica for dogs?

Simparica is an oral chewable tablet for dogs, designed to provide monthly protection against fleas, ticks, and certain types of mites. The active ingredient in Simparica is sarolaner, which acts on the nervous system of these pests, leading to their paralysis and eventual death.

  • Flea Control: It starts killing fleas within 3 hours and has a 100% efficacy within 8 hours after administration. This can be especially helpful for dogs with flea allergy dermatitis, as it reduces the itching and associated skin issues.
  • Tick Control: Simparica is effective against various ticks, protecting dogs from diseases like Lyme disease, anaplasmosis, and more.
  • Duration: One chew provides protection for up to 30 days.
  • Palatable Chew: It's a liver-flavored chewable tablet, making it easier for most dogs to consume.
  • Mite Treatment: Simparica can also be used to treat and control sarcoptic mange and ear mites.


It's essential to ensure that Simparica is appropriate for your dog, based on age, weight, and health condition. It should not be given to puppies less than 6 months old or weighing less than 2.8 lbs unless directed by a veterinarian. As with all medications, always consult with a veterinarian before starting Simparica to ensure it's the right choice for your pet.

How does Simparica work?

Simparica contains the active ingredient sarolaner, which belongs to the class of drugs known as isoxazolines. Here's how Simparica works to control fleas, ticks, and certain mites in dogs:

  • Targeting the Nervous System: Sarolaner acts on the nervous system of fleas, ticks, and some mites. Specifically, it inhibits the function of gamma-aminobutyric acid (GABA)-gated chloride channels and glutamate-gated chloride channels. This results in uncontrolled nerve activity in the pests, leading to their paralysis and death.
  • Rapid Onset: After administration, Simparica begins killing fleas within 3 hours and ticks within 8 hours.
  • Long-lasting Effect: A single dose of Simparica provides protection for up to 30 days. This means the drug continues to circulate in the dog's bloodstream, killing fleas and ticks that bite the dog for a month after administration.
  • Broad Spectrum: Simparica is effective against various species of ticks, fleas, and certain mites, offering comprehensive protection against a range of external parasites.


As with all medications, it's essential to follow the recommended dosing regimen and always consult with a veterinarian regarding the use of Simparica or any other treatments for your pet.

How long does Simparica last?

Simparica is a chewable tablet given to dogs for the control of fleas and ticks. Typically, Simparica lasts for one month (30 days). After administering, it starts killing fleas within 3 hours and ticks within 8 hours. It's essential to give your dog a Simparica tablet every month to maintain continuous protection. Always consult with your veterinarian before starting or changing any medication for your pet, and be sure to ask any questions about the appropriate dosage and duration for your dog's specific needs.

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